Human Papillomavirus and Tonsillar and Base of Tongue Cancer

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Human Papillomavirus and Tonsillar and Base of Tongue Cancer

In 2007, human papillomavirus (HPV) type 16 was recognized as a risk factor by the International Agency for Research on Cancer, for oropharyngeal squamous cell carcinoma (OSCC), where tonsillar and base of tongue cancer (TSCC and BOTSCC) dominate. Furthermore, patients with HPV-positive TSCC and BOTSCC, had a much better clinical outcome than those with corresponding HPV-negative cancer and oth...

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Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome.

Human papillomavirus (HPV) is a major etiological factor for tonsillar and the base of tongue cancer (TSCC/BOTSCC). HPV-positive and HPV-negative TSCC/BOTSCC present major differences in mutations, mRNA expression and clinical outcome. Earlier protein studies on TSCC/BOTSCC have mainly analyzed individual proteins. Here, the aim was to compare a larger set of cancer and immune related proteins ...

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Human papillomavirus in recurrent respiratory papillomatosis, tonsillar and mobile tongue cancer

The aims of this doctoral thesis were to characterize patients with recurrent respiratory papillomatosis (RRP) in northern Sweden, including voice quality and quality of life, evaluate the incidence of tonsillar cancer longitudinally in northern Sweden and to study the correlation between human papillomavirus (HPV), its surrogate marker p16 and HPV receptor syndecan-1 in tonsillar cancer and mo...

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Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3

BACKGROUND Human papillomavirus positive (HPV+) tonsillar cancer (TSCC), base of tongue cancer (BOTSCC) and unknown primary cancer of the head and neck (HNCUP) have better outcome than corresponding HPV- cancers. To find predictive markers for response to treatment, and correlations and differences in mutated oncogenes and suppressor genes between HPV+ TSCC/BOTSSCC and HPV+ HNCUP and HPV- TSCC/...

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ژورنال

عنوان ژورنال: Viruses

سال: 2015

ISSN: 1999-4915

DOI: 10.3390/v7031332